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Abstract
Introduction: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, which exhibits various clinical manifestations. There is growing interest in the exploration of new biomarkers for use as surrogate markers of disease activity and/or to predict flares of the disease. Research on metalloproteinases in SLE is inconsistent and sometimes contradictory. Objectives: The aim of this study was to define the serum level of metalloproteinase-3 (MMP-3) in patients with SLE and its relationship with the clinical activity of the disease and other biomarkers of activity used in daily practice. Materials and methods: Forty-seven SLE patients were recruited. Individual disease activity was quantified using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Twenty-five healthy volunteers were included as controls. Results: The serum levels of MMP-3 in the patients with SLE were significantly higher than those of the controls (120 ± 75 ng/ml vs 13.5 ± 6.5 ng/ ml p˂0.001), with a positive correlation (R = 0.778) between serum levels of MMP-3 and the SLEDAI and CIC-C3b (R = 0.486). Conclusions: The correlation between serum MMP-3 levels and disease activity in SLE patients suggests that MMP-3 may be involved in the inflammatory process of SLE.
References
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