Keywords
antimicrobials
carbapenemase
KPC
OXA
NDM
How to Cite
Abstract
Introduction: Carbapenems constitute one of the groups of antibiotics used in the treatment of infections caused by multiresistant Enterobacteriaceae isolated from clinical samples. Resistance to these antibiotics is caused mainly by enzymes that hydrolyze this group of antibiotics, among which the most studied are class A carbapenemases (such as KPC), class B carbapenemases (metallo beta-lactamases such as NDM, IMP and VIM) and those of class D (oxacillinases such as OXA-48 and its variants). Objectives: The present work describes the epidemiological, phenotypic and molecular characteristics of carbapenemase-producing Enterobacteriaceae (CPE) isolated in different health centers in the city of Mar del Plata, Buenos Aires, Argentina. Results: About 45% (47/103) of the isolates were producers of KPC, 44% (45/103) of OXA-163, 8% (8/103) of NDM, and 3% were double carbapenemase-producing Enterobacteriaceae (1 KPC + NDM and 2 OXA-163 + NDM). Twenty-five of the 103 strains were isolated from surveillance swab samples, while the remaining 78 were from clinical samples of infections. Klebsiella pneumoniae was the main carbapenemase-producing agent, with KPC and OXA-163-type enzymes being the most prevalent in the city. Discussion: It is of great importance to know the epidemiology of CPE, since due to the increase in the indiscriminate use of antibiotics, antimicrobial resistance has become a threat to public health.
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