Palabras clave
enfermedades metabólicas
diabetes
obesidad
Cómo citar
Resumen
Objetivos: Analizar la longitud telomérica (LT) como biomarcador del riesgo y la progresión de enfermedades metabólicas. Evaluar la LT de acuerdo con el número de alteraciones metabólicas y factores de riesgo ambientales. Materiales y Métodos: Se realizó un estudio transversal en individuos categorizados de la siguiente manera : con obesidad metabólicamente sanos (OMS); obesidad y síndrome metabólico (OSM) y un grupo control normopeso (NP). Se hicieron determinaciones bioquímico-clínicas y antropométricas y se infomaron presencia de factores de riesgo del estilo de vida y enfermedades preexistentes. La LT absoluta se determinó en ADN de sangre periférica por PCR cuantitativa. El análisis estadístico se realizó con SPSS versión 20.0 con p<0.05. Resultados: La menor LT se asoció a la presencia de anormalidades del SM y al aumento progresivo del número de componentes(p<0.001). Los OMS presentaron una LT significativamente menor que los NP (p=0.034) y mayor que los OSM (p=0.004). La menor LT se asoció con la mayor cantidad de años de ser fumador (p=0.003). Por último, el tercil más bajo de LT se asoció con mayor riesgo de presentar circunferencia de cintura aumentada (OR=2.13; p<0.001), triglicéridos altos (OR=1.68; p=0.034), dislipidemia (OR=1.86; p=0.039), obesidad (OR=2.41; p<0.001) y SM (OR=2.12; p<0.001). Conclusión: la LT puede resultar un biomarcador útil de riesgo y progresión de enfermedades metabólicas, como la enfermedad cardiovascular y la DT2.
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