Palabras clave
síndrome metabólico
obesidad
diabetes
Cómo citar
Resumen
La longitud telomérica leucocitaria absoluta (LTLa) es considerada un marcador del envejecimiento celular y podría ser un biomarcador de la prevalencia y progresión de enfermedades metabólicas. El objetivo de este estudio fue determinar la LTLa por qPCR, en un estudio transversal, su asociación con variables bioquímico - clínicas y los distintos componentes del síndrome metabólico (SM). Por otra parte, se realizaron dos estudios prospectivos controlados para evaluar los cambios en la LTLa en individuos con diabetes tipo 2 (DT2), sometidos a un tratamiento antidiabético y en pacientes con obesidad luego de una cirugía bariátrica (CB). Observamos una disminución de la LTLa con el aumento en el número de componentes del SM (0, 1, 2 componentes o SM; p<0,001), y también, diferencias entre los grupos 0 vs. 1 (p = 0,010), 0 vs. 2 (p< 0,001) y 0 vs. SM (p<0,001). En DT2 observamos cambios en la LTLa luego del tratamiento. Sin embargo, encontramos una asociación positiva significativa entre la variación de la LTLa y la dosis de metformina empleada (p = 0,048). En pacientes obesos, la LTLa aumentó significativamente a los 6 meses post-CB (p = 0,013), lo cual se debe, probablemente, al mejoramiento del estado metabólico y a la disminución del estado de inflamación observados. Este aumento se evidenció principalmente a expensas de los pacientes con obesidad mórbida, (p = 0,022), en los cuales los mayores aumentos en la LTLa se asociaron a mayores descensos en la PCR como marcador de inflamación (p = 0,024).
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