Insulinorresistencia y su asociación con síndrome metabólico en adolescentes obesos

Abstract

Insulin resistance is a primary metabolic disorder associated with obesity. It has been reported a direct relationship between obesity and metabolic syndrome in children and teen agers. Divergences have been postulated on the role of insulin resistance as a critical factor in the pathogenesis of metabolic syndrome. Objective: evaluate the association among insulin resistance, metabolic syndrome and its individual components in obese adolescents population. Descriptive cross-sectional research wich included 107 male and female obese adolescent subjects, aged 10 until 14 years old who were treated at Provincial Pediatric Hospital Nutrition Sector in Posadas, Misiones, from September 2011 until August 2012. Obesity was defined as body mass index z-score ≥ 2. Metabolic syndrome was classified according to ATP III criteria modified by Cook. Insulin resistance was assessed by using the homeostatic model log HOMA-IR ≥ 3. Obese population studied had insulin resistance 49%, metabolic syndrome 28%, and this latest group showed insulin resistance 54%. The frequency found for the components of the metabolic syndrome was: abdominal obesity 93%, hight triglyceride level 47%, decreased high density lipoprotein cholesterol 33%, blood pressure ≥ p90 23% and impaired fasting glucose 1%. It was performed a logistic regression analysis to assess the association and probability of developing metabolic syndrome or some of its components with insulin resistance. It was found that insulin resistance increases 2.5 times elevated triglyceride probability. For the metabolic syndrome and its other components analysis was not significant.