Keywords
proteinuria
dipstick
sensitivity
specificity
How to Cite
Abstract
Proteinuria and albuminuria are relevant markers to assess kidney injury and functionalism.
Early detection and treatment prevents progression to chronic kidney disease. The use of test strips
is a widespread method for screening and each laboratory should evaluate its performance for the
detection of these markers. To evaluate sensitivity, specificity and positive and negative predictive
values to detect proteinuria and albuminuria of dipstick for urine Ichem VELOCITY, Iris Laboratories.
Cross-sectional study. Four hundred and eight (408) selected consecutive 24 hour urine collection of
the who underwent the assay of albumin on total volume and simultaneously the test strip was tested
on a separate aliquot of the 1st morning urine. Of these, 256 also had protein dosage. Albuminuria
was measured by nephelometry with Immage instrument, Beckman Coulter. The strip belongs to
Ichem VELOCITY, IRIS diagnosis, automated system. The negative, traces and positive (+) categories
were analyzed. For detection of proteinuria and cut off 0.2 g / L, established by the manufacturer,
the sensitivity, specificity, PPV and NPV were 70.3 % (95 % CI 53.3 to 87.5), 84.7% (95 % CI 79.7 to
89.7), 35 % (95 % CI 22.3 to 47.7) and 96% (95 % CI 93.3 to 98.7). ROC curve for albuminuria was
performed yielding an area of 72.3 % (95 % CI 66.6 to 78.1). For cut off 3 mg / dl, the curve gives
39.4 % sensitivity and 83.5 % specificity.